COMPUTATIONAL FUNCTIONAL GENOMICS • GTEx v8 MEDIAN TPM MATRIX

AlphaGenome Multi-Omics Expression & Epigenetics

Explore high-dimensional RNA-seq expression profiles and ENCODE candidate cis-Regulatory Elements (cCREs). Analyze tissue-specific TPM abundance, promoter chromatin accessibility, and epigenetic histone landscapes across 24 human organ systems.

Target Gene:

chr17:7,668,402-7,687,550 View 3D Protein

GTEx v8 Median Expression (TPM) MAX: 48.2 TPM

Transcripts Per Million (TPM) across major human tissue types. High expression indicates core physiological or metabolic dependency.

Gene Architecture ENSG00000141510

Tumor Protein P53

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstance and cell type.

Exons: 11

Strand: Minus (-)

Canonical Isoform: ENST00000269305

Protein Size: 393 aa

ENCODE cis-Regulatory Elements (cCREs)

Epigenetic Histone Signatures:

H3K4me3 (Active Promoter)

H3K27ac (Active Enhancer)

CTCF (Chromatin Loop)

H3K27me3 (Polycomb Silent)

GTEx v8 Normalized TPM

Median gene expression quantified via Illumina TrueSeq RNA-seq from 17,382 post-mortem samples across 54 non-diseased tissue sites, normalized via Trimmed Mean of M-values (TMM).

DeepMind Sidecar Integration

Cross-links with the interactive DeepMind Biomolecular Structure Viewer sidecar (sidecar://science/biomolecular-structure-viewer) for atomic resolution 3D conformational analysis.

ClinVar & Variant Impact

Regulatory mutations in distal enhancers (dELS) disrupt transcription factor binding motifs, triggering aberrant alternative splicing or oncogenic overexpression.